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Interesting find in the Robinson Map Library today:
This is a map made in November 1945 by the IRIS group (an interim, post-OSS group, but prior to CIA). It shows the actual and proposed boundaries of a fairly troubled region, that between Italy and Yugoslavia, and the Italian population in the immediate post-WWI period. This is an area and a topic I’ve written about elsewhere, but it is interesting to see the OSS basically taking up a question that preoccupied the American Inquiry and the Paris Peace Conference.
(I’ve requested a scan of the map but this is just a quick photo.)
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This may very well be the best, most informative and most awe-inspiring 10 minutes of your day.
It leaves me absolutely speechless every time I watch it.
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New Role for RNA:Guardian of Genome Integrity
DNA molecule unwinding from a chromosome inside the nucleus of a cell. (Credit: National Human Genome Research Institute)
A new and unexpected role for RNA is identified recently: the defence of genome integrity and stability. A study published in the scientific journal Nature shows that an until now unknown class of RNA — the newly christened DDRNA — plays a key role in activation of the molecular alarms necessary to safeguard our genome when DNA damage from internal or external factors occurs.Given the importance of the cellular DNA damage response in aging, in the repression and control of tumour development, and in therapeutic treatments for cancer, the discovery could open promising avenues.Scientific community has attributed a role to RNA that is subordinate to that of DNA: the functional processes of expression of genetic information into proteins. With some known exceptions, such as the classes of tRNA and rRNA involved in the synthesis of proteins, RNA molecules were considered “fleeting” messengers necessary to carry genetic instructions from the nucleus, site of the genome, to the cytoplasm where proteins, the scaffolding of living organisms, are produced.
DDRNA: a barrier against tumour development
The DNA Damage Response or DDR is the reaction that a cell triggers to maintain its genomic integrity: when a DNA break is detected, the growth and proliferation of damaged cells are temporarily halted, thus avoiding conditions that cause genome rearrangements and mutations that might predispose to cancer or the accumulation of irreparable DNA damage and cause cellular aging.
Therefore, this system constitutes a very effective barrier to the uncontrolled cell growth that is typical of tumours.
read more here
Related articles
- Thousands Of Genes Influenced By RNA Modification (medicalnewstoday.com)
- RNA: From messenger to guardian of genome integrity (sciencedaily.com)
- RNA Modification Influences Thousands of Genes: Revolutionizes Understanding of Gene Expression (sott.net)
- Time to Re-write the Textbooks: RNA has a Fifth Base!!! (sandwalk.blogspot.com)
Rashid's Blog: A Place for Inquisitive Souls 